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Translational Neuroscience: Toward New Therapies

Edited by Karoly Nikolich and Steven E. Hyman

Published by MIT Press ISBN: 9780262029865

The Ernst Strüngmann Forum - PDF

1 - Introduction - PDF

Karoly Nikolich and Steven E. Hyman

Neurodevelopmental Disorders: A New Beginning

2 - What Do We Know about Early Onset Neurodevelopmental Disorders? - PDF

Thomas Bourgeron

3 - Psychotic Disorders and the Neurodevelopmental Continuum - PDF

Michael J. Owen

4 - Neurodevelopmental Disorders: What Is to Be Done? - PDF

Stephan Heckers, Steven E. Hyman, Thomas Bourgeron, Bruce N. Cuthbert, Raquel E. Gur, Cynthia Joyce, Andreas Meyer-Lindenberg, Michael J. Owen, and Matthew W. State

Neurodegenerative Diseases: Coming Unstuck

5 - Neurodegenerative Diseases: Where Are We Not Looking for Answers? - PDF

Walter J. Koroshetz and Lennart Mucke

6 - Preclinical and Clinical Understanding: Major Gaps in Our Understanding and Capabilities - PDF

Edward H. Koo

7 - Neurodegenerative Diseases: What Is to Be Done? - PDF

David M. Holtzman, Karoly Nikolich, Menelas N. Pangalos, Karl Broich, Nancy Y. Ip, Edward H. Koo, Walter J. Koroshetz, Eliezer Masliah, Lennart Mucke, Pierluigi Nicotera, Mareike Schnaars, and Maria Grazia Spillantini

New Tools to Drive Future Therapies

8 - How Might We Get from Genes to Circuits to Disease? - PDF

Tobias Kaiser, Yuan Mei, and Guoping Feng

9 - How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans? - PDF

Joel S. Perlmutter

10 - Pathophysiological Toolkit: Genes to Circuits - PDF

Gül Dölen, Robert C. Malenka, Joel S. Perlmutter, Nils Brose, Richard Frackowiak, Bruce N. Cuthbert, Ilka Diester, Isabelle Mansuy, Katja S. Kroker, Tobias M. Boeckers, Alvaro Pascual-Leone, Guoping Feng

Metals in the Environment as Risk Factors for Infectious Diseases

11 - Using a Stem Cell-Based Approach to Model Neurodegenerative Disease: Where Do We Stand? - PDF

Lee L. Rubin

12 - From Rodent Behavioral Models to Human Disorders - PDF

Trevor W. Robbins

13 - Bridging the Gap between Patients and Models - PDF

Ilka Diester, Franz Hefti, Isabelle Mansuy, Alvaro Pascual-Leone, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Marius Wernig, Gül Dölen, Steven E. Hyman, Lennart Mucke, Karoly Nikolich, and Bernd Sommer

Epilogue

14 - The Revolution Has Begun - PDF

Steven E. Hyman and Karoly Nikolich

Bibliography - PDF